Contents
Contributors vii
Foreword xiii
Preface xvii
Section I. Introduction to Immunology
1 Overview of the Immune System — 1
Martin F. Flajnik, Steven M. Holland, Nevil J. Singh
2 History of Immunology — 29
Edward J. Moticka
Section II. Evolution of the Immune System
3 The Insect Immune System — 52
Sara Cherry, Nicolas Buchon
4 Evolution of the Vertebrate and Lower Deuterostome Immune System — 79
Martin F. Flajnik
5 The Plant Immune System — 134
Roger W. Innes
Section III. Cellular Pathways and Processes in Immunity
6 Immunometabolism — 161
Jonathan D. Powell, Chirag H. Patel, Im- Hong Sun
7 Regulated Cell Death in the Immune System — 204
Douglas R. Green, Sebastian Ruehl
8 Lymphoid Tissues and Organs — 228
Martin F. Flajnik, Nancy H. Ruddle
9 Type I Cytokines, Interferons, and Their Receptors — 258
Achsah D. Keegan, Warren J. Leonard
10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors — 308
Carl F. Ware, Nancy H. Ruddle
11 Chemokines and Chemokine Receptors — 344
Philip M. Murphy
Section IV. Innate Immunity
12 Pattern Recognition Receptors and the IL- 1 Family — 386
Rajendra Karki, Thirumala- Devi Kanneganti
13 The Complement System — 416
Erin E. West, Claudia Kemper
14 Neutrophils — 455
Andres Hidalgo, Mariana J. Kaplan
15 Macrophages — 469
Gwendalyn J. Randolph
16 Mast Cells and Basophils — 487
Mindy Tsai, Stephen J. Galli
17 Eosinophils — 519
Elizabeth A. Jacobsen, Hirohito Kita
18 The Biology of Natural Killer Cells and Innate Lymphoid Cells — 537
Vincent Peng, Marco Colonna
Section V. Adaptive Immunity
19 The Major Histocompatibility Complex — 573
David H. Margulies, Kannan Natarajan, Jamie Rossjohn, James McCluskey
20 Classical Antigen Processing and Presentation — 622
Jonathan W. Yewdell, Paul Roche, Laurence C. Eisenlohr
21 Immunoglobulins: Structure and Function — 644
Mohamed Khass, David Wald, Neil S. Greenspan, Harry W. Schroeder, Jr
22 Immunoglobulins: Molecular Genetics — 671
Sebastian D. Fugmann
23 T Cell Antigen Receptors and Antigen Recognition — 702
Mark M. Davis, Yueh- Hsiu Chien
24 Antigen Receptor Signaling — 734
Nevil J. Singh, Gideon Wolf
25 B Cell Development in Mice — 774
Nicole Baumgarth
26 B Cell Responses — 798
Claude- Agnès Reynaud, Jean- Claude Weill
27 T Cell Development in the Thymus — 823
Avinash Bhandoola, Remy Bosselut, Yousuke Takahama
28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity — 856
John J. O’Shea, Marion Pepper, Marc K. Jenkins, Danielle A. Chisolm
29 Regulatory T Cells — 874
Ethan M. Shevach
30 CD8+ T Cell Memory — 924
Francis R. Carbone, Thomas Gebhardt
31 Cytotoxic Effector Functions — 944
Morgan Huse
Section VI. Integrative Immunology
32 Immunologic Tolerance — 971
Colin C. Anderson, Troy A. Baldwin, Peter A. Bretscher
33 Fc Receptors and Their Role in Immune Regulation and Inflammation — 1008
Jeffrey V. Ravetch, Aaron Gupta, Falk Nimmerjahn
34 Dendritic cells — 1034
Roxane Tussiwand, Pierre Guermonprez, Simon Yona
35 Gamma Delta T Cells — 1054
Adrian C. Hayday
36 CD1- Restricted T Cells — 1102
Pankaj Sharma, Florian Winau
37 Mucosal- Associated Invariant T Cells and Other MR1- Reactive T Cells — 1137
Sidonia B. G. Eckle, Wael Awad, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett
38 The Mucosal Immune System — 1178
Yasmine Belkaid, Brian L. Kelsall, Warren Strober
39 Introduction to Neuroimmunology — 1212
Andrea Francesca Salvador, Jonathan Kipnis
40 Vaccines — 1231
Bali Pulendran
41 Maternal- Fetal Immunology — 1283
Gabrielle Rizzuto, Adrian Erlebacher
Section VII. Immune Responses to Pathogens
42 Response to Parasites — 1325
David Sacks, Marion Pepper, Mary F. Fontana, P’ng Loke
43 Immune Responses to Bacteria — 1355
S. Celeste Morley, Moon H. Nahm
44 Response to Viruses — 1399
Hildegund C. J. Ertl
45 Immunology of HIV Infection — 1445
Gaurav D. Gaiha, Douglas S. Kwon
Section VIII. Immunological Disease States and Immunodeficiency
46 Autoimmunity and Autoimmune Diseases — 1465
Gustaf Christoffersson, Ken T. Coppieters, Matthias von Herrath, Dirk Homann
47 Immunologic Mechanisms of Allergic Disorders — 1515
Stéphanie Lejeune, Kari C. Nadeau, David W. Scott, Joshua D. Milner
48 Transplantation Immunology — 1549
Megan Sykes, Anita S. Chong, Markus Y. Mapara
49 Cancer Immunology and Immunotherapy — 1589
Thomas F. Gajewski, Justin Kline
50 Inborn Errors of Immunity — 1619
Isabelle Meyts, Jean- Laurent Casanova, Luigi D. Notarangelo
Index 1649
