Clinical Pharmacokinetics and Pharmacodynamics recommended

LARGER VIEW

Clinical Pharmacokinetics and Pharmacodynamics, 4e

CONCEPTS AND APPLICATIONS

By Malcolm Rowland and Thomas N. Tozer

Category:
Health Professions, Pharmacy
  • Hardback
  • 9780781750097
  • February 2010
  • 864 pages
  • List Price: £67.00
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DESCRIPTION

Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.

CONTENTS

Preface

Definition of Symbols

Non-Proprietary and Brand Names of Drugs in Text and Illustrations

    I. Basic Considerations

  • 1. Therapeutic Relevance
  • 2.Fundamental Concepts and Terminology
  • II. Exposure and Response after a Single Dose

  • 3.Kinetics Following an Intravenous Bolus Dose
  • 4.Membranes and Distribution
  • 5. Elimination
  • 6. Kinetics Following an Extravascular Dose
  • 7. Absorption
  • 8. Response Following a Single Dose
  • III. Therapeutic Regimens

  • 9.Therapeutic Window
  • 10.Constant-Rate Input
  • 11.Multiple Dose Regimens
  • IV. Individualization

  • 12.Variability
  • 13.Genetics
  • 14.Age, Weight, and Gender
  • 15.Disease
  • 16.Nonlinearities
  • 17.Drug Interactions
  • 18.Initiating and Managing Therapy
  • V. Supplemental Topics

  • 19.Distribution Kinetics
  • 20.Metabolites and Drug Response
  • 21.New! Protein Drugs
  • 22.New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data
  • Appendices

    A. Assessment of AUC

    B. Ionization and the pHPartition Hypothesis

    C. Distribution of DrugsExtensively Bound to Plasma Proteins

    D. Plasma-to-Blood Concentration Ratio

    E. Well-stirred Model of Hepatic Clearance

    F. Absorption Kinetics

    G. Wagner-Nelson Method

    H. Mean Residence Time

    I. Amount of Drug in Body on Accumulation to Plateau

    J. Answers to Study Problems

SPECIFICATIONS

ISBN
9780781750097
Publication Month
February 2010
Edition
4
Edition Type
Fourth


Product Format
Hardback
Height x Width
6452 x 4522 mm
Weight
812837 grams
Number of Pages
864 pages
Language
English


Bisacs
MEDICAL / Internal Medicine, MEDICAL / Pharmacology, MEDICAL / Pharmacy


Imprint
LWW
Publisher
LWW


Related titles
  • Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Other books by this author
  • Essentials of Pharmacokinetics and Pharmacodynamics